gluten free manjistha

Rubia cordifolia, often known as Manjistha, is a species of flowering plant in the coffee family. It has been cultivated for a red pigment derived from roots and for its various medicinal properties.

The active ingredients of rubia cordifolia include anthraquinolone glycosides, naphthoquinone, naphthoquinone glycoside, furomollugin, mollugin, alizarin, mangistin, lucidin pimeveroside, ruberythric acid, rubiprasin A,B,C, purpurin, xanthopurpurin, cyclohexapeptide, garancin and aborane triterpenoids.

The roots of Rubia cordifolia have been used as a traditional Asian and Ayurvedic medicine to treat cough, bladder and kidney stones, joint inflammation, uterine hemorrhage and urethritis. Also, it has been used as a blood purifier, as a remedy to treat skin and gastrointestinal infections, and as a libido enhancer. 

In experimental models, rubia cordifolia extract was shown to possess antioxidant activity, inhibits proliferation of hepatitis B virus, demonstrate antimicrobial and antiviral activities and increases GABA level in the brain.

Potential indications for use of rubia cordifolia in humans include:

  • Acne
  • Eczema
  • Kidney stones
  • Low libido/impotence
  • Hepatitis B
  • Prophylaxis of cancer
  • Gastrointestinal infections
  • Complex therapy of herpes simplex infection
  • Chronic bronchitis and cough
  • Adjunct therapy of chronic infections
  • Skin hyperpigmentation
  • Stress management
  • Cognitive deficiency


Potential side effects:

  • Skin discoloration
  • Nausea
  • Vomiting
  • Abdominal discomfort


Potential drug interactions:

  • Have not been reported


Relative contraindications:

  • Pregnancy
  • Lactation
  • Chronic anticoagulation therapy

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Contents: 100 Vcaps

Dosage Information:
Take 1 Vcap one to three times a day.  Patients exceeding the recommended doses must do so under the supervision of their physician due to the increased risk of potential side effects.

Selected references:

Itokawa H, Ibraheim ZZ, Qiao YF, Takeya K.  Anthraquinones, naphthohydroquinones and naphthohydroquinone dimers from Rubia cordifolia and their cytotoxic activity. Chem Pharm Bull (Tokyo). 1993 Oct;41(10):1869-72.

Kalyoncu F, Cetin B, Saglam H. Antimicrobial activity of common madder (Rubia tinctorum L.). Phytother Res. 2006 Jun;20(6):490-2.


Patil RA, Jagdale SC, Kasture SB.  Antihyperglycemic, antistress and nootropic activity of roots of Rubia cordifolia Linn. Indian J Exp Biol. 2006 Dec;44(12):987-92.


Rao GM, Rao CV, Pushpangadan P, Shirwaikar A.  Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol. 2006 Feb 20;103(3):484-90.


Son JK, Jung SJ, Jung JH, Fang Z, Lee CS, Seo CS, Moon DC, Min BS, Kim MR, Woo MH. Anticancer constituents from the roots of Rubia cordifolia L.  Chem Pharm Bull (Tokyo). 2008 Feb;56(2):213-6.



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