1 00:00:02,560 --> 00:00:06,560 So today we'll talk about another important part of 2 00:00:06,560 --> 00:00:10,480 the family of Gluten Free Remedies, which is Artemisinin. 3 00:00:11,080 --> 00:00:15,800 Artemisinin, also known in traditional Chinese 4 00:00:15,800 --> 00:00:20,940 medicine as qinghao su. It's biologically active 5 00:00:20,960 --> 00:00:26,020 ingredient, or constituent, which is found in Artemisia 6 00:00:26,020 --> 00:00:30,500 annua which is sweet wormwood. Again, this is a traditional 7 00:00:30,660 --> 00:00:34,660 Chinese remedy. So Artemisinin is a chemically 8 00:00:34,660 --> 00:00:41,100 defined remedy which was discovered by a Chinese 9 00:00:41,240 --> 00:00:46,840 scientist, Tu Youyou, and because of this discovery 10 00:00:46,840 --> 00:00:50,040 she got the Nobel Prize last year. So traditionally, 11 00:00:50,100 --> 00:00:54,740 Artemisinin as well wormwood have been used as 12 00:00:54,880 --> 00:00:56,960 anti-malarial remedies. 13 00:01:01,180 --> 00:01:04,280 So however over the last ten years, its been discovered 14 00:01:04,360 --> 00:01:08,200 that Artemisinin possesses broad biological activity. 15 00:01:09,100 --> 00:01:13,120 Not only does it work against malaria, it also works 16 00:01:13,260 --> 00:01:17,820 against various parasites. It works against certain 17 00:01:17,880 --> 00:01:22,040 worms, intestinal worms specifically. It has a very broad 18 00:01:22,100 --> 00:01:25,460 anti-microbial activity. And what is interesting is that 19 00:01:25,540 --> 00:01:31,400 it has very strong activity against Helicobacter pylori, or h. pylori 20 00:01:31,580 --> 00:01:35,420 a main microorganism causing ulcers and gastric cancer. 21 00:01:36,500 --> 00:01:39,340 It can be used as a combination therapy and is very 22 00:01:39,440 --> 00:01:42,640 efficient as a part of a combination therapy. 23 00:01:43,740 --> 00:01:47,480 In addition, Artemisin also possesses very strong 24 00:01:47,760 --> 00:01:51,660 anti-viral activity. Specifically against broad spectrum 25 00:01:51,720 --> 00:01:56,640 of herpes viruses. And these viruses in addition 26 00:01:56,760 --> 00:02:00,120 to HSV 1, 2, and 6 also include Epstein barr virus, 27 00:02:00,320 --> 00:02:04,600 and cytomegalovirus. We've been using this product 28 00:02:04,740 --> 00:02:07,620 in our clinic specifically to inhibit these infections, 29 00:02:07,940 --> 00:02:10,500 and our results are quite impressive. 30 00:02:12,560 --> 00:02:15,200 So the newest discovery about Artemisinin is that 31 00:02:15,260 --> 00:02:19,060 it also destroys microbial biofilms. And there are several 32 00:02:19,160 --> 00:02:22,280 publications saying it can be used to treat resistant 33 00:02:22,360 --> 00:02:26,460 yeast infections in combination with anti-fungal therapies. 34 00:02:30,980 --> 00:02:35,940 So in addition to its anti-viral, anti-microbial, and 35 00:02:36,040 --> 00:02:42,160 anti-parasitic activity, Artemisinin is know as an 36 00:02:42,160 --> 00:02:46,080 anti-cancer agent. It used as a solo agent and in 37 00:02:46,180 --> 00:02:49,260 combination with various chemotherapeutic agents 38 00:02:49,340 --> 00:02:51,780 to treat various forms of cancer. Such as leukemia, 39 00:02:51,940 --> 00:02:55,540 prostate cancer, liver cancer, stomach cancer, and 40 00:02:55,580 --> 00:02:59,340 lung cancer. Artemisinin also has very strong 41 00:02:59,560 --> 00:03:01,440 anti-inflammatory activity and there are several 42 00:03:01,560 --> 00:03:04,680 mechanisms of actions which it expresses. One of them 43 00:03:05,080 --> 00:03:09,200 is an inhibition of B-lymphocyte activity and proliferation. 44 00:03:09,860 --> 00:03:12,960 And because of that, there are more and more data 45 00:03:13,040 --> 00:03:15,900 that Artemisinin can be used to treat various 46 00:03:16,000 --> 00:03:19,200 autoimmune diseases such as lupus, rheumatoid 47 00:03:19,240 --> 00:03:22,460 arthritis and Sjogren's syndrome as a solo agent 48 00:03:22,620 --> 00:03:25,180 and as a part of combination therapy. 49 00:03:25,960 --> 00:03:28,020 Over the last several years we've been using 50 00:03:28,140 --> 00:03:31,500 Artemisinin in our practice to treat lupus, early 51 00:03:31,600 --> 00:03:33,880 rhuematoid arthritis and Sjogren's syndrome. 52 00:03:34,080 --> 00:03:37,620 And again, I am very impressed with our early outcomes. 53 00:03:43,760 --> 00:03:48,220 So Artemisinin can be used as solo therapy as a single 54 00:03:48,280 --> 00:03:51,100 herb, but it can also be used very efficiently in 55 00:03:51,300 --> 00:03:55,060 combination with other herbs. For example, in patients 56 00:03:55,140 --> 00:03:57,900 who have lupus and Sjogren's syndrome, we use 57 00:03:58,000 --> 00:04:00,700 Artemisinin in combination with Cordyceps Sinensis, 58 00:04:00,800 --> 00:04:03,620 which is a Chinese mushroom. To treat various 59 00:04:03,760 --> 00:04:07,000 infections inclusing for example, H. pylori, we can use 60 00:04:07,120 --> 00:04:11,640 Artemisinin in combination with Olive Leaf Extract 61 00:04:12,400 --> 00:04:15,720 Sometimes patients don't tolerate well the so-called 62 00:04:15,840 --> 00:04:18,900 die-off effect, or Herxheimer Reaction, and we are 63 00:04:19,020 --> 00:04:22,120 combining Artemisinin with Succinic Acid. Also for 64 00:04:22,260 --> 00:04:26,900 various infections, Artemisinin can be combined with 65 00:04:27,140 --> 00:04:30,240 Anantamul, Cat's Claw and Black Walnut. 66 00:04:32,060 --> 00:04:34,820 Quite frequently, we get questions whether drugs 67 00:04:34,880 --> 00:04:37,760 and herbs can be combined and what's the outcome 68 00:04:37,880 --> 00:04:41,040 of that combination? Specifically in patients with 69 00:04:41,120 --> 00:04:43,460 autoimmune diseases, we frequently combine 70 00:04:43,560 --> 00:04:45,960 Artemisinin with Plaquenil, also known as 71 00:04:46,100 --> 00:04:50,840 Hydroxychloroquine. It can be used in combination 72 00:04:50,940 --> 00:04:55,500 with quinacrine, low dose naltrexone and some other 73 00:04:55,600 --> 00:04:58,860 agents from the arsenal of Western medicine. 74 00:05:01,000 --> 00:05:05,120 For example, the recent discovery is that Artemisinin 75 00:05:05,280 --> 00:05:11,280 amplifies the anti-fungal activity of miconazole 76 00:05:11,420 --> 00:05:15,500 which is a known agent prescribed frequently to 77 00:05:15,700 --> 00:05:16,420 treat candida. 78 00:05:19,920 --> 00:05:22,120 In addition in our practice we also combine 79 00:05:22,200 --> 00:05:25,360 Artemisinin with certain anti-viral agents to treat 80 00:05:26,400 --> 00:05:30,000 Eptsein barr virus and cytomegalovirus infections. 81 00:05:30,540 --> 00:05:33,100 And again that combination is very well tolerated 82 00:05:33,280 --> 00:05:34,960 with very few if any side effects. 83 00:05:35,560 --> 00:05:38,620 Although Artemisinin in general is very well tolerated, 84 00:05:38,880 --> 00:05:41,600 you need to know that it is a very powerful 85 00:05:41,880 --> 00:05:45,680 and very strong remedy. In our clinic we observed 86 00:05:45,700 --> 00:05:49,100 several patients who demonstrated elevation of 87 00:05:49,120 --> 00:05:52,280 liver function. And therefore, we introduced the rule 88 00:05:52,320 --> 00:05:56,340 that patients who are getting Artemisinin need to 89 00:05:56,420 --> 00:05:59,740 be tested for their liver function every 1 or every 3 90 00:05:59,920 --> 00:06:01,540 months depending on the duration of the therapy. 91 00:06:02,660 --> 00:06:06,160 My personal advice is to take Artemisinin under 92 00:06:06,340 --> 00:06:10,760 physician supervision. In addition it is absolutely 93 00:06:10,820 --> 00:06:14,440 obligatory not to take Artemisinin in combination with 94 00:06:14,540 --> 00:06:18,520 alcohol because your chances of having elevated liver 95 00:06:18,720 --> 00:06:20,600 function goes up dramatically. 96 00:06:21,660 --> 00:06:24,940 And also based on published data, Artemisinin is 97 00:06:25,020 --> 00:06:28,400 strongly contraindicated for women who are 98 00:06:28,480 --> 00:06:31,340 pregnant especially during the first trimester of pregnancy.

1 00:00:06,580 --> 00:00:11,040 Today we will talk about prevention of the skin aging 2 00:00:11,260 --> 00:00:15,940 and treatment of the aged skin in a natural way. 3 00:00:16,100 --> 00:00:19,400 Some patients ask me why 4 00:00:19,560 --> 00:00:22,120 you stepped into a territory which is not 5 00:00:22,120 --> 00:00:25,020 pure rheumatology or pure autoimmune diseases 6 00:00:25,740 --> 00:00:28,220 but, it happened kind of organically. 7 00:00:28,220 --> 00:00:32,240 In our practice we have a lot of patients with gluten intolerance 8 00:00:32,460 --> 00:00:34,700 and various autoimmune diseases 9 00:00:34,700 --> 00:00:36,680 and these are the patients who are prone to 10 00:00:36,680 --> 00:00:38,380 premature aging of the skin 11 00:00:38,380 --> 00:00:41,840 and I was trying to find a natural solution to the problem 12 00:00:42,800 --> 00:00:45,280 and that's how we started our journey 13 00:00:51,900 --> 00:00:53,260 So how do we know that 14 00:00:53,260 --> 00:00:55,720 the skin ages? Well first of all you can 15 00:00:55,720 --> 00:00:58,260 wrinkles, you can see sagging of the skin. 16 00:01:00,480 --> 00:01:02,400 Changes in the skins results 17 00:01:03,060 --> 00:01:06,720 in reduced skin strength and elasticity. 18 00:01:07,700 --> 00:01:11,880 In addition the skin gets thinner, the subcutaneous fat disappears 19 00:01:12,440 --> 00:01:14,840 and the skin gets very, very prone to 20 00:01:16,460 --> 00:01:20,500 various erosions and tear and bleedings 21 00:01:21,160 --> 00:01:23,320 as well as subcutaneous bruises. 22 00:01:24,720 --> 00:01:27,920 In addition, the aged skin cannot repair itself 23 00:01:28,720 --> 00:01:32,480 fast enough and wounds typically heals much, much 24 00:01:32,780 --> 00:01:35,340 longer as compared to young patients. 25 00:01:36,180 --> 00:01:39,140 So this aging process can also contribute to 26 00:01:39,140 --> 00:01:41,540 skin ulcers and various skin infections. 27 00:01:47,900 --> 00:01:53,020 So we decided to simplify the approach to 28 00:01:54,180 --> 00:01:58,020 treat the aged skin and we developed several principles. 29 00:01:58,500 --> 00:02:01,700 Number one, we need to restore skin elasticity. 30 00:02:02,500 --> 00:02:03,680 So how can we do it? 31 00:02:03,940 --> 00:02:05,540 We need to increase production of collagen in 32 00:02:05,800 --> 00:02:08,440 the skin and we came up with two products 33 00:02:08,860 --> 00:02:10,660 which do it extremely well. 34 00:02:10,660 --> 00:02:13,100 The first product is TruMarine Collagen 35 00:02:13,660 --> 00:02:16,460 it's a Japanese product which represents 36 00:02:17,120 --> 00:02:19,320 very high-end collagen from fish skin. 37 00:02:20,080 --> 00:02:21,920 And second is vitamin C plus rosehips 38 00:02:22,480 --> 00:02:24,320 these are natural remedies 39 00:02:24,320 --> 00:02:26,640 which facilitate collagen production. 40 00:02:26,680 --> 00:02:30,340 Second you want to improve skin hydration 41 00:02:30,820 --> 00:02:32,580 and again, how can we do it? 42 00:02:32,580 --> 00:02:34,880 TruMarine collagen is a wonderful product 43 00:02:35,340 --> 00:02:37,100 to improve skin hydration 44 00:02:37,840 --> 00:02:40,320 and we decided to add hyaluronic acid 45 00:02:40,320 --> 00:02:41,900 which is a natural skin matrix 46 00:02:41,900 --> 00:02:44,060 and it retains water in the skin. 47 00:02:44,200 --> 00:02:46,200 So this is a win-win situation 48 00:02:46,540 --> 00:02:48,300 to improve skin hydration 49 00:02:49,040 --> 00:02:50,040 and skin moisture. 50 00:02:50,360 --> 00:02:53,080 The next step was trying to find a natural 51 00:02:53,240 --> 00:02:56,160 solution to improve skin repair 52 00:02:56,520 --> 00:02:58,840 and to improve the skins ability to 53 00:02:59,540 --> 00:03:01,460 heal up the ulcers and wounds 54 00:03:01,700 --> 00:03:02,620 and things like that. 55 00:03:02,660 --> 00:03:05,420 Again, TruMarine collagen makes wonders 56 00:03:05,920 --> 00:03:08,000 and finally two extra products 57 00:03:08,100 --> 00:03:09,920 which can be used very efficiently. 58 00:03:10,080 --> 00:03:12,160 It's biotin, which is a vitamin 59 00:03:12,840 --> 00:03:15,160 and Eclipta Alba, which is a famous 60 00:03:15,280 --> 00:03:16,560 Ayruvedic herb. 61 00:03:17,140 --> 00:03:20,020 In addition, biotin and eclipta alba 62 00:03:20,080 --> 00:03:22,300 stimulate nails and hair growth 63 00:03:22,500 --> 00:03:25,100 and so they can be used for this purpose. 64 00:03:25,400 --> 00:03:28,580 And finally we are talking about some cosmetic things. 65 00:03:29,020 --> 00:03:32,220 Obviously none of us wants to deal with wrinkles 66 00:03:32,660 --> 00:03:35,020 and poor tonus of the skin 67 00:03:35,260 --> 00:03:38,020 and there is a product which is an extract from 68 00:03:38,320 --> 00:03:41,320 sardines, it's called DMAE 69 00:03:41,480 --> 00:03:44,920 which stands for 2-dimethylaminoethanol 70 00:03:44,920 --> 00:03:47,560 and this is a product in clinical trials 71 00:03:47,620 --> 00:03:49,540 was shown to reduce wrinkles 72 00:03:49,540 --> 00:03:50,960 and improve skin tonus. 73 00:03:52,820 --> 00:03:54,100 So, what does it do? 74 00:03:54,860 --> 00:03:57,280 When you consume collagen, 75 00:03:57,840 --> 00:03:59,760 it degrades into amino acids 76 00:04:00,600 --> 00:04:02,600 and these amino acids migrate 77 00:04:03,120 --> 00:04:04,380 to your skin and they boost 78 00:04:04,880 --> 00:04:08,180 production of your own collagen. So that's why we 79 00:04:08,380 --> 00:04:11,020 talk about beauty from within, or beauty from the inside. 80 00:04:12,060 --> 00:04:14,840 So the newly synthesized collagen 81 00:04:15,120 --> 00:04:18,700 in your skin, increases skin elasticity 82 00:04:18,960 --> 00:04:22,000 it increases water absorption and retention 83 00:04:22,120 --> 00:04:23,720 in the skin and in addition 84 00:04:23,980 --> 00:04:25,840 one thing which we haven't mentioned 85 00:04:26,020 --> 00:04:29,020 it reduces the skin damage produced by 86 00:04:29,440 --> 00:04:31,440 ultraviolet light or sunlight. 87 00:04:36,520 --> 00:04:39,880 So the product has been on the European 88 00:04:40,060 --> 00:04:42,620 and Japanese market for several years 89 00:04:42,620 --> 00:04:44,780 and we are proud to be one of the first 90 00:04:44,880 --> 00:04:47,820 companies in the United States who introduce 91 00:04:47,960 --> 00:04:49,420 it to the U.S. customers. 92 00:04:49,540 --> 00:04:52,020 There are quite a few clinical trials 93 00:04:52,020 --> 00:04:54,460 which were published using TruMarine 94 00:04:54,460 --> 00:04:56,860 Collagen. And what's been shown that 95 00:04:57,380 --> 00:05:00,160 after taking it for three weeks 96 00:05:00,360 --> 00:05:02,780 and up to seven weeks, you can see visible 97 00:05:02,960 --> 00:05:05,040 changes in the skin. Including 98 00:05:05,440 --> 00:05:08,100 improvement of skin elasticity and skin tonus. 99 00:05:09,220 --> 00:05:11,700 The studies were done mainly in women 100 00:05:13,120 --> 00:05:16,460 but our position is that there is no 101 00:05:16,660 --> 00:05:19,540 gender differences and the product should 102 00:05:19,660 --> 00:05:21,920 work for both men and women. 103 00:05:25,640 --> 00:05:28,200 Another study done by the same company 104 00:05:28,340 --> 00:05:30,500 showed that TruMarine Collagen 105 00:05:31,160 --> 00:05:35,140 increases water retention and moisture content 106 00:05:35,460 --> 00:05:37,340 in the skin and subcutaneous tissue. 107 00:05:38,780 --> 00:05:41,000 It was a very nicely done study and 108 00:05:41,020 --> 00:05:43,480 results were obviously statistically significant 109 00:05:46,000 --> 00:05:48,080 Again, the typical duration of 110 00:05:48,700 --> 00:05:51,320 the study when you can see an 111 00:05:51,520 --> 00:05:53,620 obvious difference was two months. 112 00:05:55,720 --> 00:05:58,780 In addition, the company made a phenomenal 113 00:05:58,960 --> 00:06:02,220 observation, they actually did an animal 114 00:06:02,400 --> 00:06:04,480 study where they fed animals with 115 00:06:04,680 --> 00:06:06,880 TruMarine Collagen and then analyzed 116 00:06:06,940 --> 00:06:12,340 the skin microscopy and specifically collagen 117 00:06:12,400 --> 00:06:15,880 fibers. So what they observed is consumption 118 00:06:15,980 --> 00:06:17,520 of TruMarine Collagen by animals 119 00:06:17,640 --> 00:06:21,660 results in an increase of the collagen 120 00:06:21,740 --> 00:06:24,380 fiber diameter, which is the thickness, 121 00:06:24,380 --> 00:06:25,260 and density. 122 00:06:25,840 --> 00:06:28,920 This also stimulates production of fibroblasts. 123 00:06:29,200 --> 00:06:31,480 These are main cells which contributes 124 00:06:31,760 --> 00:06:34,000 to various skin properties. 125 00:06:34,620 --> 00:06:37,100 Again both in animal experiments and 126 00:06:37,440 --> 00:06:39,920 in humans, the product demonstrates 127 00:06:40,160 --> 00:06:42,560 phenomenal beneficial properties 128 00:06:42,680 --> 00:06:44,560 and definitely can be used very efficiently 129 00:06:44,580 --> 00:06:46,120 as a skin anti-aging product. 130 00:06:49,900 --> 00:06:52,940 The same company also ran the final 131 00:06:53,180 --> 00:06:57,980 study on TruMarine Collagen as a product 132 00:06:58,160 --> 00:07:01,420 preventing sunlight or UV induced 133 00:07:01,660 --> 00:07:04,020 skin damage and again, results were very 134 00:07:04,240 --> 00:07:06,640 very impressive, very beneficial.

1 00:00:04,400 --> 00:00:07,600 So today we will talk about integrative therapy 2 00:00:07,740 --> 00:00:12,340 for Sjogren's Syndrome. This is the protocol which 3 00:00:12,340 --> 00:00:16,940 was developed in our clinic which is Institute for Specialized Medicine 4 00:00:16,940 --> 00:00:20,220 together with Gluten Free Remedies. 5 00:00:21,120 --> 00:00:27,440 As most of you know Sjogren's Syndrome is the most common autoimmune disease affecting humans 6 00:00:27,867 --> 00:00:34,187 and specifically the disease affects women. It's much more prevalent among women than in men. 7 00:00:34,313 --> 00:00:38,633 Sjogren's Syndrome is known as a disease which can cause dryness 8 00:00:39,040 --> 00:00:44,120 and dryness can affect eyes, mouth as well as genital organs. 9 00:00:44,780 --> 00:00:53,060 So the dryness can be very debilitating and create problems with eye vision, extreme thirst and with different 10 00:00:53,060 --> 00:00:59,280 sexual dysfunctions. In addition, Sjogren's Syndrome can cause muscle pain, joint pain 11 00:01:00,047 --> 00:01:07,047 various gastrointestinal problems, neurological problems as well as problems with cognitive function. 12 00:01:08,140 --> 00:01:14,380 So Sjogren's Syndrome is an autoimmune disease which affects mainly exocrine glands. These 13 00:01:14,380 --> 00:01:25,660 are the glands which produce saliva and tears as well as glands producing various digestive enzymes, such as pancreas. 14 00:01:26,180 --> 00:01:29,900 And also it can affect glands producing sweat. 15 00:01:30,880 --> 00:01:36,720 The mechanism linked to Sjogren's Syndrome is definitely an autoimmune process 16 00:01:37,200 --> 00:01:42,400 and it results in infiltration of various exocrine glands with lymphocytes. 17 00:01:42,460 --> 00:01:48,700 Subsequently these lymphocytes become activated and they destroy normal gland tissue 18 00:01:48,800 --> 00:01:50,400 and the organ becomes dysfunctional. 19 00:01:50,480 --> 00:01:56,600 There are several key mechanisms which contribute to Sjogren's Syndrome. 20 00:01:57,220 --> 00:02:03,780 Right now there is a thinking process behind Sjogren's Syndrome that it is an autoimmune disease 21 00:02:03,900 --> 00:02:10,700 which obviously has a genetic background, but at the same time is strongly linked to certain viruses. 22 00:02:11,100 --> 00:02:15,000 Such as Epstein Barr virus known as EBV 23 00:02:15,400 --> 00:02:17,720 and cytomegalovirus known as CMV. 24 00:02:18,920 --> 00:02:26,260 So as a consequence of interplay between various viral infections and genetic factors the immune system 25 00:02:26,320 --> 00:02:28,900 gets out of control. And then what happens? 26 00:02:28,940 --> 00:02:38,840 Number one the process results in the changes in TH1 and TH2 ratio. These are T cells which mediate various 27 00:02:38,960 --> 00:02:45,660 aspects of our immune balance and the TH1 cells become dominant and they trigger various 28 00:02:45,780 --> 00:02:52,020 autoimmune responses. The second mechanism is linked to so called TH17 cells and disbalance 29 00:02:52,140 --> 00:02:58,120 between T cells which regulate normal immune response and autoimmune responses. 30 00:02:59,000 --> 00:03:08,340 As a consequence there is increased production, proliferation of TH17 cells. 31 00:03:09,340 --> 00:03:13,680 In addition, there are several well recognized markers of Sjogren's Syndrome 32 00:03:13,900 --> 00:03:19,160 which also facilitate various autoimmune problems. 33 00:03:19,740 --> 00:03:29,280 So first of all these include antibodies to SSA and SSB antigens. These antibodies are definitely pathogenic 34 00:03:29,460 --> 00:03:34,100 and they have been associated with various pathological processes. 35 00:03:34,100 --> 00:03:40,960 In addition, recently another subset of antibodies have been recognized as pathogenic. 36 00:03:41,500 --> 00:03:45,760 These are antibodies which affect muscarinic M3 receptor 37 00:03:46,580 --> 00:03:52,260 So after interaction between antibodies and M3 receptor there is a downstream event 38 00:03:52,760 --> 00:04:03,760 which affects water channel knows as aquaporin-5. And as a consequence, the cells start producing 39 00:04:03,760 --> 00:04:08,240 less and less fluid and our saliva for example gets much more viscous 40 00:04:08,431 --> 00:04:13,690 our tears become much more viscous. And so this is the whole mark of Sjogren's Syndrome. 41 00:04:13,690 --> 00:04:17,698 In addition over the last several years another pathogenic process was recognized 42 00:04:18,500 --> 00:04:24,920 and the process was linked to abnormal methylation of epithelial DNA in epithelial cells. 43 00:04:25,680 --> 00:04:31,760 As some of you know methylation is a process which regulates switching of the gene on and off 44 00:04:32,274 --> 00:04:37,971 and defective methylation can reactivate genes which in normal conditions should be dormant. 45 00:04:37,971 --> 00:04:44,607 Therefore abnormal methylation is another pathogenic process which contributes to reactivation of the autoimmune response. 46 00:04:45,520 --> 00:04:50,240 So based on pathogenisis and clinical symptoms of Sjogren's Syndrome 47 00:04:51,339 --> 00:04:55,455 there are three main goals in the therapy of Sjogren's Syndrome. 48 00:04:55,760 --> 00:05:04,040 And these goals can be achieved with either drugs or natural products and today we'll talk about natural approach to treat Sjogren's Syndrome 49 00:05:04,679 --> 00:05:07,579 and this approach can be as efficient as drugs. 50 00:05:07,760 --> 00:05:11,920 So the first process is a process focused on improving dryness 51 00:05:13,840 --> 00:05:20,060 Second we need to normalize poorly controlled autoimmune responses 52 00:05:20,560 --> 00:05:26,140 and finally one topic which also needs to be in focus is prevention of malignancies. 53 00:05:26,332 --> 00:05:31,687 So what's been shown is that patient's with Sjogren's Syndrome have significantly increased risk 54 00:05:32,104 --> 00:05:38,264 of malignancies specifically lymphomas. And controlling of Sjogren's Syndrome activity 55 00:05:38,264 --> 00:05:41,442 can significantly reduce the risk of lymphomas. 56 00:05:41,780 --> 00:05:47,140 So what is our recipe? So we created a protocol where we are using a combination of 57 00:05:47,260 --> 00:05:53,700 several natural products. And each of these products target one or two specific pathogenic mechanisms. 58 00:05:57,432 --> 00:06:01,832 So how can we improve dryness? We are using three natural products 59 00:06:01,832 --> 00:06:04,947 which we've found to be very efficient in our practice 60 00:06:05,260 --> 00:06:13,300 One is a product called SalivaStim and two oils one is Black Currant Seed Oil and Krill Oil. 61 00:06:13,440 --> 00:06:20,400 The next process is focused, or the next approach is focused on normalization of autoimmune responses. 62 00:06:21,463 --> 00:06:27,783 And for this reason we are using an extract from wormwood known as Artemisinin 63 00:06:28,420 --> 00:06:32,900 we are using a famous Chinese mushroom which is Cordyceps Sinensis 64 00:06:33,880 --> 00:06:42,760 we are using N-Acetylcysteine, we are using very concentrated broccoli extract containing high 65 00:06:43,020 --> 00:06:47,260 concentration of I3C/DIM, which is indole-3-carbinol and DIM 66 00:06:47,900 --> 00:06:51,720 as well as Krill Oil and Black Currant Seed Oil. 67 00:06:52,220 --> 00:06:59,280 Another therapeutic path is the correction of methylation defect 68 00:06:59,460 --> 00:07:04,180 that's something which can be achieved with a product called TMG Plus. 69 00:07:05,340 --> 00:07:11,880 TMG stands for Trimethylglycine, which is a key methylation agent. In addition TMG Plus 70 00:07:12,200 --> 00:07:16,660 contains methyl B-12, Methylfolate and B6. 71 00:07:17,840 --> 00:07:24,160 The normalization of methylation process is a key step in controlling of Sjogren's Syndrome. 72 00:07:24,740 --> 00:07:30,740 Finally one of the goals is to prevent malignancies or to reduce the risk of malignancies. 73 00:07:31,400 --> 00:07:34,740 And this can be achieved with three products such as 74 00:07:35,140 --> 00:07:39,780 Artemisinin, Indole-3-Carbinol/DIM and SalivaStim. 75 00:07:40,340 --> 00:07:45,560 Now we'll talk briefly about certain products that we have in our arsenal. 76 00:07:46,101 --> 00:07:51,461 The first one is Artemisinin. So Artemisinin is a chemically defined substance 77 00:07:52,573 --> 00:07:58,493 from the Chinese herb known as Wormwood. So Artemisinin has a unique scope of activities 78 00:07:59,300 --> 00:08:07,000 it does inhibit very efficiently Epstein Barr Virus and Cytomegalovirus and this unique property of 79 00:08:07,080 --> 00:08:10,700 Artemisinin we are using all of the time in our practice. 80 00:08:13,120 --> 00:08:22,480 Artemisinin also inhibits TH1 responses and it shifts TH1/TH2 ratio toward TH2. 81 00:08:22,880 --> 00:08:32,320 It also suppresses TH17 cells which facilitate autoimmune responses. And finally 82 00:08:32,400 --> 00:08:41,380 there is very strong data that Artemisinin can inhibit abnormal B cell proliferation and suppress 83 00:08:41,680 --> 00:08:46,333 autoantibody production. SalivaStim is another featured product of Gluten Free Remedies 84 00:08:46,940 --> 00:08:53,960 SalivaStim is unique because it increases expression of Aquaporin-5 85 00:08:54,520 --> 00:09:00,820 and in many clinical trials was shown to increase production of saliva and tears. 86 00:09:01,420 --> 00:09:10,340 And this is the product which it's strength is very very similar to a lot of prescription products such as 87 00:09:10,460 --> 00:09:15,952 Pilocarpine and Cevimeline known as Evoxac in terms of stimulation of saliva and tear production. 88 00:09:16,300 --> 00:09:24,620 N-Acetylcysteine is another natural product which can optimize TH1 and TH2 ratio 89 00:09:24,820 --> 00:09:31,140 as well as inhibit TH17 responses. In addition it is one of the strongest natural antioxidants 90 00:09:31,880 --> 00:09:37,880 and it stimulates production of glutathione. It is well recognized that the production of glutathione 91 00:09:38,060 --> 00:09:40,020 is inhibited in patient's with Sjogren's Syndrome. 92 00:09:40,080 --> 00:09:47,420 Another natural product which is a part of our scope of remedies for Sjogren's Syndrome is Indole-3-Carbinol/DIM 93 00:09:47,960 --> 00:09:53,880 As I mentioned before it is a natural highly concentrated extract from broccoli sprouts 94 00:09:54,440 --> 00:09:59,800 so I3C/DIM optimize TH1/TH2 responses. 95 00:10:00,420 --> 00:10:05,780 It protects salivary and lacrimal glands from the damaging effects of estrogens. 96 00:10:05,880 --> 00:10:14,120 It is very well recognized that women who are over producers of estrogen are at high risk of having Sjogren's Syndrome. 97 00:10:14,660 --> 00:10:25,960 In addition it protects epithelial cells and lacrimal glands from certain environmental factors 98 00:10:26,177 --> 00:10:29,257 and it also possesses a very strong antiviral activity. 99 00:10:29,420 --> 00:10:37,080 Black Currant Seed Oil and Krill Oil are natural products which normalize TH1 and TH2 responses 100 00:10:37,720 --> 00:10:43,320 as well as inhibit various inflammatory processes through COX1/COX2 mechanisms. 101 00:10:44,080 --> 00:10:50,460 Cordyceps Sinensis is used in our practice as a very very synergistic product with Artemisinin 102 00:10:50,763 --> 00:10:56,366 It's a classical combination of traditional Chinese medicine. In addition by itself it has certain 103 00:10:56,460 --> 00:11:02,780 antiviral and antimicrobial activity and it is also capable of normalizing TH1 and TH2 responses. 104 00:11:03,100 --> 00:11:08,840 The next slide shows the dosage regime which we are using in our practice. 105 00:11:08,980 --> 00:11:11,540 There are a couple of comments that I want to make 106 00:11:11,720 --> 00:11:16,560 In general, we start our patients on one product at a time 107 00:11:16,880 --> 00:11:19,200 and we try one product for three or four days, see 108 00:11:19,460 --> 00:11:22,460 how patients tolerate them and then we will move forward with the second one. 109 00:11:23,880 --> 00:11:27,400 So among all products that are listed on this slide, I 110 00:11:27,520 --> 00:11:30,480 want to specifically mention Artemisinin. 111 00:11:30,920 --> 00:11:33,780 As a part of good practice, I would strongly recommend 112 00:11:34,020 --> 00:11:37,158 to check liver function at least every 6-8 weeks 113 00:11:37,869 --> 00:11:39,968 in patients who take Artemisinin. 114 00:11:40,845 --> 00:11:46,605 Because there is a small chance that Artemisinin can cause non-specific liver damage 115 00:11:46,605 --> 00:11:48,337 and elevation of liver enzymes. 116 00:11:48,639 --> 00:11:52,399 So Sjogren's Syndrome not only affects salivary glands 117 00:11:52,520 --> 00:11:55,720 and lacrimal glands, but also can cause a number 118 00:11:55,800 --> 00:11:58,435 of satellite problems such as various gastrointestinal 119 00:11:59,442 --> 00:12:02,622 problems including dysmotility, poor production of 120 00:12:03,040 --> 00:12:05,520 digestive enzymes and so on and so on. 121 00:12:06,060 --> 00:12:09,200 And because of the dryness quite a few patients who have Sjogren's Syndrome 122 00:12:09,342 --> 00:12:13,033 they are dealing with chronic candida or yeast infection. 123 00:12:13,999 --> 00:12:17,759 Because of that we are using some supplements as a part of 124 00:12:18,060 --> 00:12:21,340 the adjunct therapy. These supplements include 125 00:12:22,360 --> 00:12:24,018 known things such as digestive enzymes 126 00:12:25,407 --> 00:12:28,287 Triphala, which helps us to move the bowel. 127 00:12:28,287 --> 00:12:35,177 Probiotics, prebiotics and the scope of leaky gut products which are available as a part of Gluten Free Remedies 128 00:12:36,446 --> 00:12:40,286 In addition, as a part of candida control or yeast control 129 00:12:40,286 --> 00:12:42,508 we are using our featured product Candidacillin 130 00:12:43,520 --> 00:12:47,280 in a combination with Berberine and Black Walnut Hulls. 131 00:12:49,180 --> 00:12:54,140 That's the protocol which we would like to introduce and that's the protocol which we have been using in 132 00:12:54,280 --> 00:12:56,640 our practice for a while with great success.

1 00:00:05,940 --> 00:00:07,940 Today we will talk about gout. 2 00:00:08,760 --> 00:00:10,460 Gout is one of the most common forms of arthritis, 3 00:00:10,880 --> 00:00:18,080 which we see in our clinic. And it affects males and females. 4 00:00:18,760 --> 00:00:23,200 It affects mainly women after menopause 5 00:00:24,200 --> 00:00:28,360 and in terms of men, it affects men independent from their age. 6 00:00:28,420 --> 00:00:32,500 We have actually young males with gout and old males with gout. 7 00:00:33,740 --> 00:00:37,020 So what is gout? Gout is a form of arthritis 8 00:00:38,480 --> 00:00:44,480 Which is caused by elevated levels of uric acid. 9 00:00:45,380 --> 00:00:49,300 When uric acid reaches critical concentrations 10 00:00:49,740 --> 00:00:54,220 it forms crystals and the crystals are deposited in various joints 11 00:00:54,740 --> 00:00:59,420 causing inflammation, pain and swelling of the affected joints. 12 00:00:59,811 --> 00:01:02,135 What do we need to know about uric acid? 13 00:01:02,800 --> 00:01:05,520 Uric acid is produced in the liver mainly 14 00:01:06,380 --> 00:01:09,900 the main enzyme which is responsible for production 15 00:01:10,200 --> 00:01:14,780 of urid acid is called xanthine oxidase. And most 16 00:01:15,080 --> 00:01:18,240 of the drugs available on the market right now 17 00:01:18,560 --> 00:01:21,360 are specifically targeting this enzyme. 18 00:01:21,640 --> 00:01:25,800 Elimination of uric acid is mediated mainly through 19 00:01:26,360 --> 00:01:29,320 kidneys, approximately 60-70% of uric acid 20 00:01:29,600 --> 00:01:32,230 produced in our body is eliminated through kidneys 21 00:01:32,600 --> 00:01:35,480 and the rest through the gastrointestinal tract. 22 00:01:35,500 --> 00:01:37,680 So we are talking about 30-40%. 23 00:01:39,040 --> 00:01:43,240 There is an enzyme which can also participate in 24 00:01:43,540 --> 00:01:46,580 degredation of uric acid and it has a long name 25 00:01:47,300 --> 00:01:52,980 Hypoxanthine-guanine Phosphoribosyltransferase 26 00:01:53,260 --> 00:01:58,160 and there is an abbreviation for that enzyme; it's called HGPRT 27 00:01:59,200 --> 00:02:04,140 This is a critical enzyme which is kind of opposite 28 00:02:04,340 --> 00:02:08,720 of xanthine oxidase and this enzyme lowers levels of uric acid. 29 00:02:09,127 --> 00:02:11,747 At this point there are not too many drugs available 30 00:02:11,860 --> 00:02:15,260 to control these enzymes, but there are quite a few supplements available. 31 00:02:15,480 --> 00:02:20,040 So what is interesting is that genetically in males, 32 00:02:20,180 --> 00:02:23,860 activity of this particular enzyme is much lower than in females 33 00:02:24,200 --> 00:02:27,960 and it's one of the reasons why young males have 34 00:02:28,202 --> 00:02:30,726 much more problem with gout than young women. 35 00:02:37,260 --> 00:02:40,620 When we are dealing with gout, there are two issues 36 00:02:40,959 --> 00:02:44,079 which we need to discuss. Issue number one, how 37 00:02:44,180 --> 00:02:49,900 do we deal with acute gouty attacks when a person or patient is in severe pain. 38 00:02:50,711 --> 00:02:53,831 And number two how do we control uric acid level 39 00:02:54,220 --> 00:02:57,260 from being elevated and how we can prevent the 40 00:02:57,520 --> 00:03:00,720 development of crystals, and how we can prevent 41 00:03:01,360 --> 00:03:04,327 flare ups of gout. We are not going to talk about 42 00:03:04,500 --> 00:03:06,560 medications because you can find plenty of 43 00:03:06,700 --> 00:03:10,140 information on the internet and in various publications. 44 00:03:10,420 --> 00:03:14,320 Today we will talk mainly about natural way of dealing with gout 45 00:03:15,200 --> 00:03:17,480 Actually, the number of natural supplements 46 00:03:17,500 --> 00:03:21,260 available for gout is much more than the number of drugs 47 00:03:21,300 --> 00:03:24,760 available for gout. So if a person or patient has an 48 00:03:25,120 --> 00:03:27,280 acute gouty attack what do we do? 49 00:03:27,520 --> 00:03:29,740 We are using herbs and supplements which have 50 00:03:30,480 --> 00:03:33,415 strong anti-inflammatory activity. For example, in 51 00:03:33,840 --> 00:03:37,520 our clinic we are using a very popular herb. It's called 52 00:03:37,960 --> 00:03:43,540 Devil's Claw, in addition we are using an herb from 53 00:03:43,540 --> 00:03:46,720 Amazonian rainforest from Peru, it's called Iporuru 54 00:03:47,240 --> 00:03:52,860 Also we are using Boswellia/Curcumin for the same reason 55 00:03:53,640 --> 00:03:56,440 and in addition, what's been shown is that 56 00:03:57,140 --> 00:04:01,740 high-dose fish oil combined with Methylfolate 57 00:04:02,020 --> 00:04:05,380 and Alpha Lipoic Acid can significantly reduce an acute 58 00:04:05,400 --> 00:04:09,940 inflammatory reaction caused, or triggerd by uric acid crystals. 59 00:04:14,800 --> 00:04:19,520 Next step is prevention of gouty attacks or maintenance of gout. 60 00:04:20,160 --> 00:04:22,960 So how do we handle it? So there are several 61 00:04:23,340 --> 00:04:26,300 natural remedies which are very efficient. 62 00:04:27,500 --> 00:04:31,660 Number one is White Chinese Mulberry Extract 63 00:04:32,100 --> 00:04:35,580 known as morus albus. So this particular 64 00:04:35,580 --> 00:04:40,720 product has a chemically defined ingredient, which is called murine 65 00:04:41,360 --> 00:04:44,660 and murine is a natural inhibitor of xanthine oxidase 66 00:04:45,120 --> 00:04:48,320 it also stimulates the elimination of uric acid 67 00:04:48,320 --> 00:04:51,069 through the kidneys. So it has double beneficial affect. 68 00:04:51,880 --> 00:04:58,180 So murine is found both in roots and in fruits 69 00:04:58,320 --> 00:05:02,520 of Chinese mulberry and we carry in stock highly 70 00:05:02,660 --> 00:05:04,660 concentrated fruit extract. 71 00:05:05,740 --> 00:05:08,300 The next product is Alpha Lipoic Acid. 72 00:05:08,460 --> 00:05:11,960 Alpha Lipoic Acid has a unique property. So 73 00:05:12,100 --> 00:05:14,849 Alpha Lipoic Acid stimulates the degredation 74 00:05:14,849 --> 00:05:17,640 of uric acid and can be combined with White 75 00:05:17,760 --> 00:05:21,220 Chinese Mulberry Extract as a very powerful 76 00:05:21,300 --> 00:05:22,260 combination. 77 00:05:23,240 --> 00:05:26,680 So in order to speed up the elimination of uric acid, 78 00:05:27,180 --> 00:05:29,302 through gastrointestinal tract, we are utilizing 79 00:05:29,920 --> 00:05:36,600 yucca root extract, which is known as Yucca Schidigera. And this product works as a soap 80 00:05:36,710 --> 00:05:41,190 so it kind of washes out uric acid from the gastrointestinal tract. 81 00:05:41,860 --> 00:05:45,497 In addition we have a brand product called liver detoxifier 82 00:05:45,640 --> 00:05:51,000 which eliminates uric acid through liver via increased 83 00:05:51,480 --> 00:05:55,053 elimination with bile and then through the gastrointestinal tract. 84 00:05:55,640 --> 00:06:00,680 Finally, two oils, Black Currant Seed Oil and Krill Oil 85 00:06:00,740 --> 00:06:05,100 can significantly reduce production of uric acid in 86 00:06:05,160 --> 00:06:09,360 the liver and also benefit patients who are trying to lower uric acid.

1 00:00:04,060 --> 00:00:09,080 So as most of you know intestinal candidiasis 2 00:00:09,500 --> 00:00:12,380 or a yeast infection in the gut represents a 3 00:00:12,540 --> 00:00:16,020 very sizeable problem in patients with various 4 00:00:16,140 --> 00:00:20,000 autoimmune diseases. And we were trying to find 5 00:00:20,200 --> 00:00:22,920 the best solution and so far we think that 6 00:00:23,160 --> 00:00:24,800 Candidacillin is one of the best remedies 7 00:00:24,860 --> 00:00:27,562 available on the market of nutraceuticals 8 00:00:27,960 --> 00:00:31,860 or food supplements. So where do we stand 9 00:00:32,100 --> 00:00:36,100 with candida? Well, candida is a part of 10 00:00:36,240 --> 00:00:39,280 normal gut, or intestinal microflora. Under 11 00:00:39,400 --> 00:00:42,440 appropriate conditions, candida starts to overgrow 12 00:00:42,820 --> 00:00:45,380 and occupies much more space in the gut 13 00:00:45,660 --> 00:00:47,680 compared to what it should be 14 00:00:48,020 --> 00:00:51,560 and as a consequence, people with intestinal candidiasis 15 00:00:51,620 --> 00:00:54,620 develop different problems varying from bloating 16 00:00:54,960 --> 00:00:59,820 fatigue, brain fog, headaches, as well as various 17 00:00:59,920 --> 00:01:03,080 inflammatory conditions. So why does yeast 18 00:01:03,180 --> 00:01:07,040 become so aggressive? There are two reasons. 19 00:01:07,200 --> 00:01:10,180 Reason number one, it occupies more space in the gut 20 00:01:10,180 --> 00:01:13,460 and is much more metabolized. Reason number two, 21 00:01:13,720 --> 00:01:15,960 that it becomes more pathogenic. 22 00:01:16,340 --> 00:01:19,940 So what does that mean? Yeast exists in two forms 23 00:01:20,220 --> 00:01:26,840 round forms and hyphae. Round forms are low pathogenic 24 00:01:27,100 --> 00:01:29,842 and don't represent any harm for the human body. 25 00:01:30,080 --> 00:01:32,820 The budding forms, or hyphae, are much more 26 00:01:32,840 --> 00:01:35,700 pathogenic, they are invasive forms and they can 27 00:01:35,780 --> 00:01:38,800 produce various toxins affecting our body and 28 00:01:38,800 --> 00:01:41,280 overstimulating the immune system. 29 00:01:41,680 --> 00:01:45,700 So when we target candida, or yeast, we need to 30 00:01:45,920 --> 00:01:49,460 keep three things in mind. And target three different 31 00:01:49,460 --> 00:01:52,420 areas. Number one, we need to bring the yeast 32 00:01:52,560 --> 00:01:55,720 count under control. Number two, we need to 33 00:01:55,860 --> 00:01:59,620 prevent the hyphae formation and finally, we need 34 00:01:59,620 --> 00:02:00,956 to prevent biofilm formation. 35 00:02:01,467 --> 00:02:03,578 I didn't talk much about biofilm 36 00:02:03,660 --> 00:02:07,420 but yeast forms biofilm and biofilm prevents 37 00:02:07,460 --> 00:02:10,920 various antibiotics from their antifungal activities. 38 00:02:11,143 --> 00:02:14,183 Candidacillin, which we designed recently, 39 00:02:14,183 --> 00:02:16,603 represents a combination of four ingredients. 40 00:02:16,860 --> 00:02:22,340 Number one is calcium salt of undecylenic acid 41 00:02:22,520 --> 00:02:26,460 which is an FDA approved remedy to treat candida 42 00:02:26,840 --> 00:02:31,520 this is an extract from castor oil and it has 43 00:02:31,600 --> 00:02:34,800 fungicidal activities so what it does, it kills 44 00:02:34,820 --> 00:02:39,000 the yeast cells. Number two, we have two ingredients 45 00:02:39,000 --> 00:02:42,360 from coconuts, or coconut oil more specifically, 46 00:02:42,600 --> 00:02:45,900 one is Monolaurin and second is Caprylic acid 47 00:02:46,060 --> 00:02:48,920 both ingredients reduce the candida count 48 00:02:49,100 --> 00:02:52,300 or yeast count in the gut and they kill the yeast as well. 49 00:02:52,720 --> 00:02:55,420 And finally we decided to add EDTA. 50 00:02:56,320 --> 00:02:59,260 EDTA is a chelating agent which binds calcium 51 00:02:59,420 --> 00:03:02,537 and various heavy metals and destroys the biofilms. 52 00:03:03,140 --> 00:03:05,780 So by combining these four ingredients 53 00:03:05,780 --> 00:03:07,960 together, we created a very efficient, natural 54 00:03:07,960 --> 00:03:09,720 remedy to handle candida. 55 00:03:14,720 --> 00:03:16,880 So what about the dosage of Candidacillin? 56 00:03:17,120 --> 00:03:19,940 We recommend a dose of two capsules of 57 00:03:20,260 --> 00:03:24,340 candidacillin before meals twice a day. 58 00:03:24,720 --> 00:03:26,720 So you can take it before breakfast and before lunch 59 00:03:26,900 --> 00:03:29,780 or before lunch and before dinner. Ideally 60 00:03:29,880 --> 00:03:31,020 you need to drink plenty of fluid and take it 61 00:03:31,020 --> 00:03:34,420 around 20-30 minutes before meals.