There are many dietary supplements one can use as natural remedies for dry eyes, dry mouth and dry skin.  After years of using this traditional list, we wanted to see if there was something else we could design to help our patients. Based on the research we found two ingredients from aruyveda that have been used for thousands of years….and designed SalivaStim. Many people suffering from Sjogren’s Syndrome find great relief and satisfaction from this product.

A basic explanation of what SalivaStim is targeting

We have muscarinic M3 receptors located in our exocrine glands, that help stimulate secretion in salivary glands.

There are antibodies (proteins produced in response to an antigen) affecting the muscarinic M3 receptor that have been detected in the serum of patients with Sjogren’s syndrome.

This interaction between antibodies and the M3 receptor creates a downstream event which affects our water channel protein known as aquaporin-5.

Aquaporin-5 plays a role in generating saliva, tears and sweat. In patients with Sjogren’s syndrome, this protein is suppressed and the cells start producing less and less fluid causing our saliva and tears to become much more viscous.

How SalivaStim restores moisture

Dendrobium nobile
The extract from dendrobium nobile increases production of aquaporin-5 and by doing that, it restores the production of saliva and tears in those who have dryness. There are several clinical trials that show that dendrobium nobile is very efficient in patients with Sjogren’s syndrome.

The second herb in SalivaStim is a product from the Amazonian rainforest, Smilax medica, also known as Sarsaparilla. Is an herb that not only stimulates sweat and fluids in our body, but also has very strong anti-inflammatory and detoxifying properties which improves exocrine gland function.

Indications for use

Eye and mouth dryness
Vaginal dryness
Skin dryness
Sjogren’s syndrome
Atrophic gastritis

How to take SalivaStim?

Each capsule contains 400 mg of Dendrobium nobile and 100 mg of Smilax medica/Sarsaparilla.

Our recommendation is to start slow and gradually increase the dose up to a comfortable level. Initially we recommend taking one capsule (500 mg) a day for a week or two then increase to two capsules a day. We don’t recommend going above two capsules.

The expectation is that you may experience around 60 to 65% increase in production of saliva and tears after taking SalivaStim for one week.

SalivaStim should be taken early in the morning because it can stimulate your brain and cause insomnia.

To view supplement facts click here

Dr. Shikhman discuss the benefits of SalivaStim

You can purchase SalivaStim in our online store.

Relative contraindications:

Chronic anticoagulation therapy
Gastritis Esophagitis
Peptic ulcer disease
Seizures or history of seizures


For years I always felt like I had sand in my eyes and that is now gone and I am thrilled. It took about 2 weeks to notice a difference and it’s been such a relief. I sweat a little bit more, but I’ve had no other side effects. I’ve also noticed my energy level has increased. Jordan W.

I’ve had Sjogren’s Syndrome for years and have been taking Evozac, which has been helpful but I didn’t like the excessive sweat I would get around my neck. I started taking SalivaStim and have been very pleased. My dry eyes and mouth have eased with no side effects. It took a few days to notice a difference, it was a subtle build, but now I can tell a difference when I don’t take it. My afternoon energy has increased as well. Sheryl M.

Selected references:

Jiang J, Xu Q. Immunomodulatory activity of the aqueous extract from rhizome of Smilax glabra in the later phase of adjuvant-induced arthritis in rats. J Ethnopharmacol. 2003 Mar;85(1):53-9.

Lam Y, Ng TB, Yao RM, Shi J, Xu K, Sze SC, Zhang KY. Evaluation of chemical constituents and important mechanisms of pharmacological biology in dendrobium plants. Evid Based Complement Alternat Med. 2015;2015:841752.

Lin X, Liu J, Chung W, Sze SC, Li H, Lao L, Zhang Y. Polysaccharides of Dendrobium officinale induce aquaporin 5 translocation by activating M3 muscarinic receptors. Planta Med. 2015 Jan;81(2):130-7.

Lin X, Shaw PC, Sze SC, Tong Y, Zhang Y. Dendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjögren’s syndrome mice. Int Immunopharmacol. 2011 Dec;11(12):2025-32.

Sautour M, Miyamoto T, Lacaille-Dubois MA. Bioactive steroidal saponins from Smilax medica. Planta Med. 2006 Jun;72(7):667-70.

Sautour M, Miyamoto T, Lacaille-Dubois MA. Steroidal saponins from Smilax medica and their antifungal activity. J Nat Prod. 2005 Oct;68(10):1489-93.

Xiang L, Stephen Sze CW, Ng TB, Tong Y, Shaw PC, Sydney Tang CW, Kalin Zhang YB. Polysaccharides of Dendrobium officinale inhibit TNF-α-induced apoptosis in A-253 cell line. Inflamm Res. 2013 Mar;62(3):313-24.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. All information contained on this website is intended for informational and educational purposes only, and is not intended nor suited to be a replacement or substitute for professional medical treatment or for professional medical advice relative to a specific medical question or condition.

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