Pantothenic acid

As co-enzymes, the B vitamins are essential components in most major metabolic reactions. They play an important role in energy production, including the metabolism of lipids, carbohydrates, and proteins. B-vitamins support the vital roles they play in energy production, antioxidant support and maintenance of healthy blood cells, nervous system, hormonal balance, and more. As water-soluble substances, B vitamins are not generally stored in the body in any appreciable amounts (with the exception of vitamin B-12). Therefore, the body needs an adequate supply of B vitamins on a daily basis.


Pantothenic acid, also known as vitamin B-5, is a coenzyme essential for energy production from dietary proteins, fats and carbohydrates. It is a component of coenzyme A and of phosphopantetheine, and is therefore essential for Krebs cycle operation.


Potential side effects:

  • Gastrointestinal discomfort
  • Diarrhea

Potential drug interactions:

  • Levodopa
  • Prednisone
  • Methylprednisolone
  • Tricyclic antidepressants
  • Coumadin

Relative contraindications:

  • Pregnancy
  • Lactation
  • Chronic anticoagulation therapy
  • Adrenal tumors


Contents: 60 capsules

Dosage information:
The recommended dose of pantethine is 300 mg 2 to 3 times a day. Those exceeding the recommended doses must do so under the supervision of their physician due to the increased risk of potential side effects.


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Selected references:

Friberg G, Pande J, Ogun O, Benedek GB. Pantethine inhibits the formation of high-Tc protein aggregates in gamma B crystallin solutions. Curr Eye Res. 1996 Dec;15(12):1182-90.


Horváth Z, Vécsei L. Current medical aspects of pantethine. Ideggyogy Sz. 2009 Jul 30;62(7-8):220-9.


Osono Y, Hirose N, Nakajima K, Hata Y. The effects of pantethine on fatty liver and fat distribution. J Atheroscler Thromb. 2000;7(1):55-8.


Rumberger JA, Napolitano J, Azumano I, Kamiya T, Evans M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. Nutr Res. 2011 Aug;31(8):608-15.



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