Licorice Root

gluten free licorice root

Licorice (Glycyrrhiza glabra) is a legume (related to beans and peas) that is native to southern Europe and parts of Asia. Licorice root has been used in both Eastern and Western medicine to treat a variety of illnesses ranging from the common cold to liver disease.


The major biologically active component of licorice root is a saponin known as glycyrrhizin or glycyrrhizic acid. It has a chemical structure and activity similar to the adrenal steroid hormones. Other active ingredients of the licorice root include bioflavonoids such as liquiritin, isoliquiritin, liquiritigenin and isoliquiritigenin. Presumably, they are responsible, in part, for the anti-ulcer activity of the plant.


Potential side effects:

  • Hypertension
  • Headaches
  • Fatigue
  • Chest pain
  • Low blood potassium level
  • Fluid retention
  • Leg swelling
  • Generalized muscle pain
  • Tingling and numbness of hands and feet

Potential drug interactions:

  • Ace inhibitors and diuretics (water pills)
  • MAO inhibitors
  • Digoxin
  • Fludrocortisone
  • Hydrocortisone, prednisone, methylprednisolone, dexamethasone
  • Insulin or drugs for diabetes
  • Laxatives
  • Oral contraceptives

Relative contraindications:

  • Pregnancy
  • Lactation
  • Congestive heart failure
  • Coronary artery disease
  • Fluid retention
  • High blood pressure (hypertension)
  • Diabetes
  • Hypokalemia (low potassium)
  • Liver cirrhosis
  • Alcoholic liver/fatty liver disease


Contents: 100 caps


Dosage information:

The recommended dose of licorice root is 900 mg taken 1 to 3 times a day. Those exceeding the recommended doses must do so under the supervision of their physician due to the increased risk of potential side effects.


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Selected references:

Aly AM, Al-Alousi L, Salem HA. Licorice: a possible anti-inflammatory and anti-ulcer drug. AAPS PharmSciTech. 2005 Sep 20;6(1):E74-82.


Armanini D, Fiore C, Mattarello MJ, Bielenberg J, Palermo M. History of the endocrine effects of licorice. Exp Clin Endocrinol Diabetes. 2002 Sep;110(6):257-61.


Asl MN, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res. 2008 Jun;22(6):709-24.


Fiore C, Eisenhut M, Krausse R, Ragazzi E, Pellati D, Armanini D, Bielenberg J. Antiviral effects of Glycyrrhiza species. Phytother Res. 2008 Feb;22(2):141-8.


Fiore C, Eisenhut M, Ragazzi E, Zanchin G, Armanini D. A history of the therapeutic use of liquorice in Europe. J Ethnopharmacol. 2005 Jul 14;99(3):317-24.


Reuter J, Wölfle U, Weckesser S, Schempp C. Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex. J Dtsch Dermatol Ges. 2010 Oct;8(10):788-96. doi: 10.1111/j.1610-0387.2010.07496.x.


Wittschier N, Faller G, Hensel A. Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa. J Ethnopharmacol. 2009 Sep 7;125(2):218-23.




These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

All information contained on this website is intended for informational and educational purposes only, and is not intended nor suited to be a replacement or substitute for professional medical treatment or for professional medical advice relative to a specific medical question or condition.


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