BoneDense (Drynaria)

Gluten free drynaria

Drynaria fortunei, commonly known in China as Gu-Sui-Bu, is a species of basket fern of the family Polypodiaceae. The plant is native to Eastern Asia, including eastern China. Preparations from the roots of drynaria have been used in traditional Asian medicine for aiding in the healing of bone fractures and for treating rheumatoid arthritis.

Excessive bone loss, known as osteopenia or osteoporosis, is characterized by imbalance between the bone-destroying cells, osteoclasts, and bone-building cells, osteoblasts. Human and animal data showed that drynaria inhibiting osteoclast function without entirely halting it, as bisphosphonate drugs (alendronate, risedronate, ibandronate etc) do. It stimulates osteoblasts to produce more healthy bone tissue. In addition, drynaria attracts mesenchymal stem cells to accelerate the damaged bone repair. Drynaria has been shown to provide anti-osteoporotic effects in female mammals following the loss of ovaries and in animals with experimental osteoporosis induced by rheumatoid arthritis.

In addition, drynaria extract exhibits an anti-inflammatory activity, protect kidney from renal failure and possess an anti-tumor activity against multiple myeloma.

Potential indications for use of drynaria in humans include:

  • Osteopenia
  • Osteoporosis
  • Poor dental health
  • Periodontal gum disease
  • Prevention of bone loss in postmenopausal women and people with rheumatoid arthritis, diabetes and those who take steroids (prednisone) on a long-term basis
  • Inflammation and pain management in patients with rheumatoid arthritis and osteoarthritis
  • Adjunct therapy of multiple myeloma
  • Adjunct therapy of renal insufficiency

Potential side effects:

  • Dizziness and lightheadedness
  • Mild nausea
  • Gastrointestinal discomfort

Potential drug interactions:

  • Bisphosphonates (alendronate, risedronate, ibandronate etc)
  • Calcitonin
  • Denosumab (prolia)
  • Teriparatide (Forteo)
  • Coumadin


  • Pregnancy
  • Lactation
  • Chronic anticoagulation therapy

Complementary natural products:

  • Biotin
  • Calcium Lactate
  • Indian Thorny Bamboo
  • Magnesium Malate
  • Strontium Citrate
  • Taurine
  • Vitamin D

Dosage Information:
The recommended daily dose of BoneDense varies from 500 to 1500 mg twice a day taken before meals. The consumption of BoneDense and strontium citrate should be spaced out by at least 2 hours.


Contents: 100 Vcaps


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Anuja GI1, Latha PG, Suja SR, Shyamal S, Shine VJ, Sini S, Pradeep S, Shikha P, Rajasekharan S. Anti-inflammatory and analgesic properties of Drynaria quercifolia (L.) J. Smith. J Ethnopharmacol. 2010 Nov 11;132(2):456-60.


English,Jim. Drynaria-Benefits of Unique Bone Building Herb for Gingivitis and Osteoporosis Nutrition Review.
2014 July 17.

Hung TY1, Chen TL, Liao MH, Ho WP, Liu DZ, Chuang WC, Chen RM. Drynaria fortunei J. Sm. promotes osteoblast maturation by inducing differentiation-related gene expression and protecting against oxidative stress-induced apoptotic insults. J Ethnopharmacol. 2010 Aug 19;131(1):70-7.

Li B1, Duan T, Fan L. On the inhibitory effect of Drynaria fortunei extract on human myeloma SP20 cells. Afr J Tradit Complement Altern Med. 2013 Aug 12;10(5):375-9.

Li F1, Meng F, Xiong Z, Li Y, Liu R, Liu H. Stimulative activity of Drynaria fortunei (Kunze) J. Sm. extracts and two of its flavonoids on the proliferation of osteoblastic like cells. Pharmazie. 2006 Nov;61(11):962-5.

Wang XL1, Wang NL, Gao H, Zhang G, Qin L, Wong MS, Yao XS. Phenylpropanoid and flavonoids from osteoprotective fraction of Drynaria fortunei. Nat Prod Res. 2010 Aug;24(13):1206-13.

Wong KC1, Pang WY, Wang XL, Mok SK, Lai WP, Chow HK, Leung PC, Yao XS, Wong MS. Drynaria fortunei-derived total flavonoid fraction and isolated compounds exert oestrogen-like protective effects in bone. Br J Nutr. 2013 Aug 28;110(3):475-85.

Zhang P1, Dai KR, Yan SG, Yan WQ, Zhang C, Chen DQ, Xu B, Xu ZW. Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell. Eur J Pharmacol. 2009 Apr 1;607(1-3):1-5.




These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

All information contained on this website is intended for informational and educational purposes only, and is not intended nor suited to be a replacement or substitute for professional medical treatment or for professional medical advice relative to a specific medical question or condition.

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