Chromium Polynicotinate

gluten free chromium polynicotinate

Chromium polynicotinate consists of niacin-bound chromium and represents a natural product stabilizing the binding of insulin to insulin receptor on cell membranes. It is a part of GTF, Glucose Tolerance Factor.


Chromium polynicotinate optimizes insulin action, regulates hunger and food cravings, normalizes lipid metabolism and protects cardiac muscle.


In contrast to chromium picolinate, it does not damage human DNA.

Potential side effects:

  • Hypoglycemia (low blood sugar)
  • Dizziness and light-headedness
  • Mild nausea
  • Gastrointestinal discomfort

Potential drug interactions:

  • Beta-blockers
  • NSAIDs (nonsteroidal anti-inflammatory drugs) – ibuprofen, naproxen, diclophenac etc
  • Prednisone, methylprednisolone
  • Acarbose
  • Glimepiride
  • Glipizide
  • Glyburide
  • Insulin
  • Metformin
  • Miglitol
  • Pioglitazone
  • Repaglinide
  • Rosiglitazone
  • Tolazamide
  • Troglitazone
  • Coumadin
  • Antacids
  • Proton pump inhibitors - omeprazole (Prilosec), lansoprazole ( Prevacid), dexlansoprazole (Kapidex, Dexilant), esomeprazole (Nexium), pantoprazole (Protonix), rabeprazole (AcipHex).
  • H2-blockers-cimetidine, ranitidine, famotidine, and nizatidine

Relative contraindications:

  • Pregnancy
  • Lactation
  • Hypoglycemia (low blood sugar)
  • Chronic anticoagulation therapy


Contents: 90 caps


Dosage information:
The recommended dose of chromium polynicotinate varies from 200 to 400 mcg three times a day 30 to 40 min after regular meals. Those exceeding the recommended doses must do so under the supervision of their physician due to the increased risk of potential side effects.


To view supplement facts click here


Selected references:

McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psychiatry. 1999 Apr;60(4):237-40.


Preuss HG, Jarrell ST, Scheckenbach R, Lieberman S, Anderson RA. Comparative effects of chromium, vanadium and gymnema sylvestre on sugar-induced blood pressure elevations in SHR. J Am Coll Nutr. 1998 Apr;17(2):116-23.


Preuss HG, Montamarry S, Echard B, Scheckenbach R, Bagchi D. Long-term effects of chromium, grape seed extract, and zinc on various metabolic parameters of rats. Mol Cell Biochem. 2001 Jul;223(1-2):95-102.


Preuss HG, Wallerstedt D, Talpur N, Tutuncuoglu SO, Echard B, Myers A, Bui M, Bagchi D. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. J Med. 2000;31(5-6):227-46.


Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem. 2003 Oct;252(1-2):369-77.



These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

All information contained on this website is intended for informational and educational purposes only, and is not intended nor suited to be a replacement or substitute for professional medical treatment or for professional medical advice relative to a specific medical question or condition.

Related Supplements


  • Coronary Artery Disease Prevention
  • Fatty Liver Disease/Alcoholic Liver
  • Hyperglycemia/Diabetes
  • Hyperlipidemia/Elevated Cholesterol
  • Obesity

Leave a Reply

Your email address will not be published. Required fields are marked *