Neem is an extract of leaves and bark of an Asian tree, Azadirachta indica, and is considered one of the principal remedies in Ayurvedic medicine. Traditionally, neem is used to treat parasites, bacterial, fungal, viral infections, and various skin diseases. In addition, neem is used as an herbal contraceptive, sedative and as a remedy to treat diabetes and cancer. The known active constituents of neem extract include nimbin, azadirachtin, nimbidiol, quercetin and nimbidin, among others. Experimental data indicate that neem components inhibit poliovirus and herpes viruses, possesses bactericidal activity toward gram positive and gram negative bacteria, fungi and parasites. It also stimulates TH1-dependent immune responses, inhibits growth of cancer cells, stimulates utilization of glucose, and inhibits growth of new blood vessels (neoangiogenesis).
Potential indications for use of neem in humans include:
- Adjunct therapy of intestinal infections
- Adjunct therapy of leprosy
- Treatment of intestinal parasites
- Treatment of candida
- Treatment of infection due to herpes virus type 1
- Treatment of malaria
- Adjunct therapy of diabetes
- Treatment of gingivitis/gum inflammation
- Treatment of eczema
- Treatment of ring worms
- Adjunct therapy of malignancies
- Treatment of head lice
- Contraceptive activity
- Treatment of gastric and duodenal ulcers
- Treatment of bronchitis and asthma
Potential side effects:
- Extremely rare side effects associated with neem overdose include seizures and loss of consciousness
Potential drug interactions:
- Drugs to treat diabetes: glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
- Immunosuppressants: azathioprine (Imuran), cyclosporine (Neoral, Sandimmune), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune)
- Coumadin (Warfarin)
- Chronic immunosupressive therapy
- Chronic anticoagulation therapy
- Ongoing therapy for infertility
- Neem is contraindicated for use in children
Contents: 100 Vcaps
Take one Vcap one to three times daily. Patients exceeding the recommended doses must do so under the supervision of their physician due to the increased risk of potential side effects.
Bose A, Chakraborty K, Sarkar K, Goswami S, Haque E, Chakraborty T, Ghosh D, Roy S, Laskar S, Baral R. Neem leaf glycoprotein directs T-bet-associated type 1 immune commitment. Hum Immunol. 2009 Jan;70(1):6-15.
Chatterjee A, Saluja M, Singh N, Kandwal A. To evaluate the antigingivitis and antipalque effect of an Azadirachta indica (neem) mouthrinse on plaque induced gingivitis: A double-blind, randomized, controlled trial. J Indian Soc Periodontol. 2011 Oct;15(4):398-401.
Mahapatra S, Young CY, Kohli M, Karnes RJ, Klee EW, Holmes MW, Tindall DJ, Donkena KV. Antiangiogenic Effects and Therapeutic Targets of Azadirachta indica Leaf Extract in Endothelial Cells. Evid Based Complement Alternat Med. 2012;2012:303019.
Nair R, Kalariya T, Chanda S. Antibacterial activity of some plant extracts used in folk medicine. J Herb Pharmacother. 2007;7(3-4):191-201.
Schmahl G, Al-Rasheid KA, Abdel-Ghaffar F, Klimpel S, Mehlhorn H. The efficacy of neem seed extracts (Tre-san, MiteStop on a broad spectrum of pests and parasites. Parasitol Res. 2010 Jul;107(2):261-9.
Paul R, Prasad M, Sah NK. Anticancer biology of Azadirachta indica L (neem): a mini review. Cancer Biol Ther. 2011 Sep 15;12(6):467-76.
Perez-Gutierrez RM, Damian-Guzman M. Meliacinolin: a potent α-glucosidase and α-amylase inhibitor isolated from Azadirachta indica leaves and in vivo antidiabetic property in streptozotocin-nicotinamide-induced type 2 diabetes in mice. Biol Pharm Bull. 2012;35(9):1516-24.
Tiwari V, Darmani NA, Yue BY, Shukla D. In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection. Phytother Res. 2010 Aug;24(8):1132-40.
This statement has not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. All information contained on this website is intended for informational and educational purposes only, and is not intended nor suited to be a replacement or substitute for professional medical treatment or for professional medical advice relative to a specific medical question or condition.