We have designed a unique dietary supplement that provides all natural pain relief that you will only find at Gluten Free Remedies. No matter what your condition, treating chronic pain is one of the main symptoms we are asked to treat. If pain can be managed with dietary supplements, we strongly support their use as they allow people an all natural pain relief alternative to drugs.
Our newest product, Agmatine/DL-Phenylalanine/GABA, is designed to provide all natural pain relief. It’s like a natural prescription for pain without the concern drugs can carry. If you google Agmatine, you will see many articles for its use in body building and sports, but there are a few very important studies that have been done on its effectiveness for treating pain.
The three ingredients: Agmatine Sulfate, DL-Phenylalanine, and GABA, we believe; will create a very effective all natural pain relief treatment.
These ingredients work on the neural pathways to inhibit pain receptors. Here is a breakdown of each of the ingredients and how they work.
Agmatine is derived from L-arginine, and is considered to be a neurotransmitter. It is stored in neurons and is released during neuronal activation.
Neurons are nerve cells that transmit information throughout the body. Neurotransmitters are needed to send the information from one neuron to the next. Examples of neurotransmitters are endorphins, dopamine, and serotonin.
Agmatine is observed to release several types of endorphins and natural opioid substances in the brain.
The most promising study on agmatine for pain reduction was done on people suffering from serious back pain from lumbar radiculopathy where there was a pinching of the nerve root in the spinal column. In the study, scientists gave varying doses of agmatine sulfate (or placebo) over 10 – 21 days.
Continuous improvement of symptoms occurred in both groups, but was more pronounced in the agmatine as compared with the placebo group. Expressed as percent of baseline values, significantly enhanced improvement in average pain measures and in quality of life scores occurred after treatment in the agmatine group (70.8%) as compared with placebo (20.0%).
The results showed that the agmatine supplement significantly improved pain symptoms and improved the quality of life for those involved.
One of the other benefits of Agmatine is that it Enhances the Pain-Relieving Effects of Opiates (e.g. Morphine) which may allow for lower doses of addictive substances in the treatment of pain management.
In research studies, Agmatine has been shown to provide pain relief from symptoms of thermal hyperalgesia for short periods of time.
This is a condition in which the body has a painful response to changes in the detection of temperatures. The body may become hypersensitive to heat or cold. Agmatine improved pain sensations, which may be a result of its pro-circulatory effects.
DL-Phenylalanine is useful in the management of pain. A number of studies have emerged indicating that DL-Phenylalanine may be very effective for reducing sensations of pain, especially chronic pain.
Enkephalin is a pentapeptide that regulates pain perception in the body. D-Phenylalanine is capable of blocking enkephalinase, an enzyme which degrades enkephalins thus preventing the breakdown of enkephalins allowing for longer-lasting pain relief.
Scientists have also suggested that our body regulates DL-Phenylalanine through a system called the ‘endogenous analgesia system‘ (EAS).
The EAS is a neural (nervous system) pathway involved in reducing pain sensations.
Since enkephalins are a key neurotransmitter in the EAS, measures which promote enkephalin activity, such as D-phenylalanine, should increase the power of EAS-mediated analgesia (the inability to feel pain).
Experimental and limited clinical data showed that inhibition of enkephalinase amplifies the efficacy of painkillers, enabling dosage reductions and enhances the analgesic effect of acupuncture.
Gamma-Aminobutyric Acid is an inhibitory neurotransmitter. The role of GABA is to inhibit or reduce the activity of neurons or nerve cells helping to control fear and anxiety when neurons become overexcited. GABA is found in spinal nerve cells and act as a pain inhibitor. When GABA is diminished, your pain system goes out of control increasing tension, anxiety, and pain. By replenishing GABA, pain is decreased.
Some of the most common reasons GABA levels become diminished are:
- Chronic stress and adrenal fatigue
- Gut microbiome dysbiosis
- Poor sleep
GABA is especially helpful with neuropathic pain which is pain stemming from nerve damage.
Signs of neuropathy can include:
- Gradual onset of numbness, prickling or tingling in your feet or hands, which can spread upward into your legs and arms
- Sharp, jabbing, throbbing, freezing or burning pain
- Extreme sensitivity to touch
- Lack of coordination and falling
- Muscle weakness or paralysis if motor nerves are affected
How long does it take for this product to work?
If taking a capsule or with a meal, the effects may take up to 45 minutes to kick in. If you are just beginning to take the product, we recommend taking one capsule a day and going up to 4 capsules a day as needed.
WARNING: This product cannot be taken with Naltrexone, even at low doses.
In the unique combination of these ingredients, we have created a product that may provide many with a natural chronic pain relief solution. Shop Now! We look forward to hearing your feedback!